Bronchocentric granulomatosis: a review and thoughts on pathogenesis

Bronchocentric granulomatosis has no specific clinical, radiological or immunological features, the diagnosis remains that of morphology on biopsy or resected lung tissue. The morphological features of bronchocentric granulomatosis can occur in a variety of situations and we believe this pathology reflects one of the limited ways in which bronchi can respond to injury, the essential requirement for its development being a sustained and/or intense inflammatory insult within the bronchial lumen.