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Related Experiment Videos

Gas gangrene.

G B Hart, R C Lamb, M B Strauss

    The Journal of Trauma
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Gas gangrene remains a threat, but combined therapy including surgery, antibiotics, and hyperbaric oxygen (HBO) significantly improves survival rates for clostridial myonecrosis.

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    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Surgical Pathology

    Background:

    • Histotoxic clostridia continue to cause severe morbidity and mortality, despite advances in medical care.
    • Gas gangrene, or clostridial myonecrosis, requires prompt and aggressive management.
    • Optimal treatment strategies for gas gangrene are crucial for patient outcomes.

    Purpose of the Study:

    • To review the literature on gas gangrene management.
    • To report on a large clinical series of patients treated with combined therapy.
    • To evaluate the efficacy of antibiotics, surgery, and hyperbaric oxygen in treating clostridial myonecrosis.

    Main Methods:

    • A 20-year literature review was conducted (Part I).
    • A 15-year clinical experience with 139 patients treated with combined therapy was analyzed (Part II).

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  • Treatment involved early recognition, surgical intervention, antibiotics, and hyperbaric oxygen (HBO).

    • Main Results:

    • The combined therapy achieved an 81% survival rate (112 out of 139 patients).
    • Mortality was concentrated in patients admitted in shock (27 deaths).
    • Mortality was 5% in post-traumatic extremity clostridial myonecrosis; age, comorbidities, and treatment delay increased risk.

    Conclusions:

    • Combined therapy of early recognition, surgery, antibiotics, and HBO is optimal for gas gangrene.
    • Prompt treatment is critical, especially for patients in shock.
    • Aggressive combined treatment significantly reduces mortality from clostridial myonecrosis.