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M-type 57 group A streptococcus bacteriocin.

W J Simpson, J R Tagg

    Canadian Journal of Microbiology
    |October 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Group A streptococci produce a bacteriocin-like substance, streptococcin A-M57 (SA-M57), with distinct inhibitory activity. This substance

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    Area of Science:

    • Microbiology
    • Bacteriology
    • Streptococcal Infections

    Background:

    • Group A streptococci (GAS) are significant human pathogens.
    • M-type 57 strains of GAS exhibit specific inhibitory patterns.
    • Bacteriocin production is a known virulence factor in some bacteria.

    Purpose of the Study:

    • To characterize the inhibitory substance produced by M-type 57 group A streptococci.
    • To investigate the properties and production of streptococcin A-M57 (SA-M57).

    Main Methods:

    • Deferred antagonism assays with indicator strains.
    • Partial purification of SA-M57 using ammonium sulphate fractionation and column chromatography.
    • Molecular weight determination using Sephadex G-100 chromatography.

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  • Sensitivity testing (protease, heat) and activity assessment.

    • Main Results:

    • All tested M-type 57 GAS isolates produced a consistent inhibitory pattern (P-type 614).
    • A bacteriocin-like substance, SA-M57, was identified as a key component of this inhibition.
    • SA-M57 production was enhanced by blood and alkaline pH.
    • Two molecular weight forms of SA-M57 (alpha and beta) were identified, both protease and heat sensitive.
    • Human plasma enhanced SA-M57's adsorption to and killing of sensitive cells.
    • SA-M57 production was independent of M protein production.

    Conclusions:

    • M-type 57 group A streptococci produce a potent bacteriocin, SA-M57.
    • SA-M57 exhibits unique characteristics, including distinct molecular forms and enhanced activity with plasma.
    • The findings contribute to understanding GAS virulence mechanisms and potential therapeutic targets.