Related Experiment Video
Updated: Aug 2, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
Coordinated responses of glucogenic hormones to central glucopenia: the role of the sympathoadrenal system
Abstract:
In normal humans glucagon plays a primary role in promoting glucose recovery from hypoglycemia, glucagon deficiency is largely compensated for by enhanced epinephrine secretion, and recovery from hypoglycemia fails to occur only in the absence of both glucagon and epinephrine. Defective glucose counterregulation is exemplified by patients with insulin-dependent diabetes. Although most such patients have deficient glucagon secretory responses to hypoglycemia, they counterregulate adequately because of intact epinephrine secretion. Some patients, however, become defenseless against hypoglycemia because of combined deficiencies of glucagon and epinephrine.
More Related Videos
08:32Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
06:30Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
Published on: September 11, 2018
Related Concept Videos
Hypothalamic-Pituitary Axis
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Hormones of the Adrenal Glands
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Hypoglycemia and Glucagon
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...