Enzyme linked immunosorbent assay of rubella antibody

Serum rubella IgG and IgM antibodies were determined in normal healthy women and in rubella patients using rubella Enzyme Linked Immunosorbent Assay (ELISA) kits. Fifty four per cent (67/125) of healthy women had IgG rubella antibodies. Positive correlation was found between rubella ELISA IgG antibody and rubella hemagglutination inhibition (HI) test. Elevation of rubella IgM antibody was demonstrated during acute phase of the rubella infection. It was concluded that the ELISA of rubella antibody can be useful in surveying the immune status of a population before performing vaccination and in diagnosing rubella during acute phase.