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The lung as an immunologic organ.

Annual Review of Medicine

|January 1, 1984

Summary

The lungs play a significant role in the body's immune system. Pulmonary immune responses vary by lung region and are influenced by factors like prior exposure and antigen type.

Area of Science:

Immunology
Pulmonary Medicine
Respiratory System Health

Background:

The lungs are increasingly recognized as a critical component of the immune system.
Existing research highlights the lungs' substantial contribution to host defense.
Understanding pulmonary immunity is crucial for respiratory health.

Purpose of the Study:

To review and summarize existing information on the lungs' role in immunity.
To discuss the factors influencing pulmonary immune responses.
To explore the regulation and augmentation of lung-based immunity.

Main Methods:

Literature review and synthesis of existing data.
Analysis of factors affecting immune response quantity and quality in the lungs.

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Discussion of regulatory mechanisms and potential therapeutic strategies.

Main Results:

The lungs are a major contributor to overall immunity.
Pulmonary immune responses exhibit regional variations in quantity and quality.
Immune response magnitude and type are modulated by prior exposure, antigen characteristics, and dose.

Conclusions:

The lungs possess a complex and regionally distinct immune system.
Pulmonary immunity is adaptable and influenced by multiple external and internal factors.
Strategies to regulate and enhance lung immunity hold therapeutic potential.