An evaluation of single-dose metronidazole treatment for Gardnerella vaginalis vaginitis

A randomized, nonblinded study was carried out to evaluate the efficacy of a single 2-g oral dose of metronidazole (Flagyl) versus a seven-day regimen in the treatment of "nonspecific" vaginitis. Using cultures for Gardnerella vaginalis, 14 (67%) of 21 women treated with the single 2-g dose and 19 (86%) of 21 women receiving the seven-day course were considered cured seven to ten days after treatment (P greater than .10). No difference in compliance was noted between the two groups, and the incidence of side effects likewise, was comparable.