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Related Experiment Videos

Coated charcoal haemoperfusion.

T M Chang

    Life Support Systems : the Journal of the European Society for Artificial Organs
    |April 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Artificial cell technology microencapsulates charcoal, preventing powder release and platelet removal. This innovation enhances hemoperfusion devices for treating conditions like drug poisoning and organ failure.

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    Area of Science:

    • Biomaterials Science
    • Artificial Cell Technology
    • Hemoperfusion

    Background:

    • Microencapsulation of activated charcoal using artificial cell principles.
    • Development of coated charcoal hemoperfusion devices since 1970.
    • Variability in existing coated charcoal systems regarding membrane properties and hemocompatibility.

    Purpose of the Study:

    • To present advancements in coated charcoal hemoperfusion technology.
    • To highlight the blood compatibility of collodion membrane-coated charcoal.
    • To explore extensions of albumin-coated systems for novel therapeutic applications.

    Main Methods:

    • Microencapsulation of activated charcoal granules with an ultrathin membrane.
    • Clinical trials for acute drug poisoning, chronic renal failure, and liver failure.

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  • Adsorption of albumin onto collodion membranes for enhanced blood compatibility.

    • Main Results:

    • Collodion membrane-coated charcoal demonstrates sufficient blood compatibility for uremia and acute intoxication.
    • Albumin coating of collodion charcoal improves hemocompatibility, especially for sensitive platelets in hepatic failure.
    • Extended applications include protein A-coated immunosorbents for cancer therapy and albumin-coated immunoadsorbents.

    Conclusions:

    • Microencapsulated charcoal offers a safer alternative to free charcoal in hemoperfusion.
    • Albumin and protein A modifications enhance the hemocompatibility and therapeutic potential of coated charcoal systems.
    • These advancements pave the way for improved hemoperfusion therapies in various clinical settings.