[Morphogenesis of candidiasis granuloma]

Fungi C. albicans killed by various methods were injected intravenously to mice resulting in the granuloma formation in the liver and spleen. These granulomas were similar to those developing in newborns affected with candidiasis. The components of the fungus cellular wall are responsible for the granuloma development and act as the antigenic material. Polynuclears which are capable of dealing with the antigenic material more actively than mononuclear liver phagocytes, play an essential role as the trigger mechanism in the granuloma formation produced by the killer C. albicans. At the same time long persistence of C. albicans antigenic material in the granulomas proves the deficiency of the phagocytic response directed to the utilization of this material. It is assumed that similar mechanisms are responsible for the morphogenesis of both human candidiasis granulomas and those produced by the killed C. albicans.