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Related Experiment Videos

Nickel--an essential element.

M Anke, B Groppel, H Kronemann

    IARC Scientific Publications
    |January 1, 1984
    PubMed
    Summary

    Nickel is an essential element vital for metabolism and enzyme function in bacteria and vertebrates. While essential, primary nickel deficiency is unlikely in humans and animals due to sufficient dietary availability.

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    Area of Science:

    • Biochemistry
    • Trace Element Research
    • Animal Nutrition

    Background:

    • Nickel is crucial for essential enzyme biosynthesis in bacteria, including hydrogenase and carbon monoxide dehydrogenase.
    • Nickel proteins, like urease from plants, can influence animal digestion in the rumen.
    • Nickel is a constituent of all vertebrate organs, with controllable absorption.

    Purpose of the Study:

    • To highlight the essential role of nickel in biological systems.
    • To discuss the consequences of nickel deficiency in vertebrates.
    • To evaluate the likelihood of primary nickel deficiency in humans and animals.

    Main Methods:

    • Literature review on nickel's biological functions and deficiency effects.
    • Analysis of nickel's role in enzyme systems and metabolism.
    • Assessment of dietary nickel availability versus requirements.

    Main Results:

    • Nickel deficiency impairs growth, reduces lifespan, and causes anemia by affecting iron absorption.
    • Nickel deficiency disrupts calcium incorporation into bones and affects zinc metabolism, leading to parakeratosis-like symptoms.
    • Nickel deficiency lowers the activity of key enzymes like dehydrogenases, transaminases, and alpha-amylase, significantly impacting carbohydrate, fat, and glycogen metabolism.

    Conclusions:

    • Nickel is an essential element with vital metabolic functions.
    • Primary nickel deficiency is improbable in humans and animals given current dietary nickel levels.
    • Further consideration of nickel's essentiality is warranted, similar to historical perspectives on manganese.

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