[Multiple brain tumors with von Recklinghausen's disease]

Area of Science:

• Neuro-oncology
• Neurosurgery
• Genetics

Background:

• Von Recklinghausen's disease (neurofibromatosis type 1) can present with multiple brain tumors.
• Surgical and conservative management strategies vary for these complex cases.

Observation:

• Nine cases of neurofibromatosis type 1 with multiple brain tumors were analyzed.
• Tumor types included bilateral acoustic neurinomas, multiple neurinomas, multiple meningiomas, and mixed tumors.
• Surgical approaches ranged from total to partial extirpation and staged procedures.

Findings:

• Total single-stage resection resulted in mortality within ten months.
• Partial resection had varied outcomes, with some long-term survivors dependent on family.
• Two-stage total resection demonstrated favorable postoperative courses.
• Conservative management yielded mixed results, including survival with severe deficits and mortality.

Implications:

• Staged surgical resection may offer improved outcomes for multiple brain tumors in neurofibromatosis type 1.
• Individualized treatment strategies are crucial for managing complex neurofibromatosis-associated brain tumors.
• Further research into optimal management protocols is warranted.