[Optimal dosage in peroral therapy of acne with vitamin A palmitate]

Successful oral therapy with vitamin A palmitate in acne vulgaris requires 150,000-200,000 I.U. daily for months. Side-effects were evaluated in 22 patients and in addition in 54 patients receiving 400,000 and 300,000 I.U. respectively for 3-4 weeks (SGPT, GGPT, Quick, electrophoresis, creatinine, bromosulfthaleine excretion). The same tests were done in 32 patients, who had received vitamin A palmitate 150,000-200,000 I.U. daily for at least half a year. Clinical experience and the presented data allow the following conclusions: There is no risk of liver impairement when 150,000-200,000 I.U. are given daily over extended periods. Doses over 300,000 I.U. are accompanied with liver impairement. During long-term treatment y-GT test should be performed regularly. Contraceptive advices are recommended.