Thyroxine deiodination during in vitro lipid peroxidation of rat liver inner membrane particles

Thyroxine inhibitory action was observed during in vitro Fe2+ induced lipid peroxidation of rat liver mitochondrial inner membrane particles. In the course of lipid peroxidation thyroxine was degraded preferentially to reverse triiodothyronine. Inhibition of lipid peroxidation by EDTA abolished the formation of reverse triiodothyronine. Nonenzymic deiodination of thyroxine leading to reverse triiodothyronine production may be of a considerable importance in various pathological states accompanied by lipid peroxidation.