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Modified NF method for quantitative determination of pentaerythritol tetranitrate
Journal of Pharmaceutical Sciences
|May 1, 1978
Summary
A new method simplifies the quantitative determination of pentaerythritol tetranitrate (PETN). This faster approach reduces analysis time by 75% compared to the standard NF method.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- The National Formulary (NF) method for pentaerythritol tetranitrate (PETN) determination is time-consuming.
- Accurate quantification of PETN is crucial for pharmaceutical quality control.
Purpose of the Study:
- To report a modified NF method for the quantitative determination of PETN.
- To develop a more time-efficient analytical procedure.
Main Methods:
- Directly preparing a solution of the powder from the dosage form using glacial acetic acid.
- Reacting the solution with phenoldisulfonic acid TS.
Main Results:
- The modified method significantly reduces analysis time, saving approximately 75% compared to the original NF method.
- The method was validated on six commercial dosage forms with varying colors and three other active ingredients.
Conclusions:
- The modified NF method provides a faster and efficient alternative for the quantitative determination of PETN.
- This streamlined approach is suitable for routine pharmaceutical analysis and quality control.