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Indomethacin suppresses prolactin release in men
Hinyokika Kiyo. Acta Urologica Japonica
|January 1, 1984
Summary
Intrarectal indomethacin significantly lowered serum prolactin in men. This non-steroidal anti-inflammatory drug did not significantly affect luteinizing hormone or follicle-stimulating hormone levels.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Prolactin is a hormone with diverse physiological roles.
- Non-steroidal anti-inflammatory drugs (NSAIDs) can influence hormonal pathways.
Purpose of the Study:
- To investigate the effect of intrarectal indomethacin on serum hormone levels in men.
- To assess the impact of indomethacin on prolactin, luteinizing hormone (LH), and follicle-stimulating hormone (FSH).
Main Methods:
- Indomethacin was administered intrarectally at a 100 mg dose.
- Serum levels of prolactin, LH, and FSH were measured post-administration.
Main Results:
- A statistically significant decrease in serum prolactin was observed.
- Serum LH levels showed a slight, non-significant decrease.
- Serum FSH concentrations remained unaffected.
Conclusions:
- Intrarectal indomethacin effectively reduces serum prolactin levels in men.
- Indomethacin does not significantly alter LH or FSH levels when administered intrarectally.