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Related Experiment Videos

Imipramine-induced inappropriate ADH secretion.

B Liskin, B T Walsh, S P Roose

    Journal of Clinical Psychopharmacology
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

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    Syndrome of inappropriate antidiuretic hormone secretion (SIADH) can occur with antidepressants. This case highlights SIADH association with imipramine and bupropion, expanding known drug-induced SIADH.

    Area of Science:

    • Endocrinology
    • Pharmacology
    • Neuroscience

    Background:

    • Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a hyponatremia condition.
    • Antidepressants are commonly prescribed, but drug-induced SIADH is a known adverse effect.

    Observation:

    • A patient developed SIADH during treatment with multiple antidepressant medications.
    • Rechallenge confirmed imipramine, a tricyclic antidepressant, as a cause of SIADH.
    • SIADH also appeared to be associated with bupropion, a novel antidepressant.

    Findings:

    • This case report identifies a potential association between imipramine and SIADH.
    • It also suggests a possible link between bupropion and SIADH.
    • These findings expand the list of antidepressants associated with SIADH.

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    Implications:

    • Clinicians should be aware of the potential for SIADH with imipramine and bupropion.
    • Further research is needed to confirm the causal relationship between these antidepressants and SIADH.
    • Monitoring electrolyte levels in patients taking these medications may be warranted.