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Bone remodeling due to continuously applied loads.

J B Meade, S C Cowin, J J Klawitter

Calcified Tissue International

|January 1, 1984

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Applying continuous compressive loads to bone tissue in dogs increased bone size but resulted in weaker, less organized new bone. This study quanties bone

Area of Science:

Orthopedics
Biomaterials Science
Bone Physiology

Background:

Bone structure is known to be influenced by stress history.
The precise relationship between stress and bone adaptation is not fully understood.

Purpose of the Study:

To quantitatively alter the stress history of in vivo bone tissue.
To investigate subsequent changes in bone's structural and material properties.

Main Methods:

Continuous compressive loads (12-130 N) were applied to the diaphysis of dog femurs for 2 months.
Mechanical compression testing was performed on bone specimens.
Cross-sectional area, ash weight, and microstructure were analyzed.

Main Results:

Related Experiment Videos

A positive correlation was observed between increased cross-sectional area and applied stress.

New bone deposition occurred primarily on the periosteal surface.

Newly formed bone exhibited lower ash weight, disorganized microstructure, and reduced stiffness compared to original bone.

Conclusions:

Superimposed mechanical stress can induce periosteal bone apposition.
The newly formed bone has inferior material properties compared to mature bone.
This suggests that altered stress environments may compromise bone quality.