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Updated: Aug 12, 2026

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
Published on: February 12, 2015
Effect of cigarette smoking on the tidal carbon dioxide profile
Abstract:
Four indices have been tested for quantitative description of the form of the expiratory partial pressure carbon dioxide curves within a group of 80 male smokers with normal routine spirometry. The control group consisted of 60 healthy nonsmokers whose age and residence matched those of the smokers. The tests demonstrated statistically significant differences between smokers and the control group. Gamma angle index and planimetric index displayed high sensitivity to the quantitative description of the capnographic curves, whereas the concomitant cough and sputum production or the smoking index did not. The data produced show that capnographic indices provide valuable data on ventilation-perfusion ratio dysfunction and also, indirectly, on small airways on smokers with normal conventional spirometry.
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