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Toxicity and association of polycyanoacrylate nanoparticles with hepatocytes
J Kreuter1, C G Wilson, J R Fry
1Department of Pharmaceutics, Swiss Federal Institute of Technology ETH, Zurich.
Journal of Microencapsulation
|July 1, 1984
Abstract:
The degradation of polybutylcyanoacrylate (PBC) and polyhexylcyanoacrylate (PHC) nanoparticles, together with their association with and toxicity towards isolated hepatocytes, were determined. Nanoparticles were not taken up by rat hepatocytes at a significant level. The LD50S of PBC and PHC nanoparticles towards hepatocytes were 0.4 mg/2 x 10(6) cells and greater than 1 mg/2 x 10(6) cells respectively. This hepatocyte toxicity cannot be attributed solely to the formaldehyde formed during degradation.