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A monoclonal antibody blocking human T cell function.
European Journal of Immunology
|October 1, 1980
Summary
The anti-T3 antibody blocks T cell proliferation and B cell help, indicating its crucial role in T cell function and antigen recognition. This suggests the T3 molecule is vital for immune responses.
Area of Science:
- Immunology
- Cell Biology
Background:
- T cell surface antigens play a role in immune responses.
- Monoclonal antibodies are tools to investigate cell surface molecules.
Purpose of the Study:
- To investigate the functional role of T cell surface antigens defined by monoclonal antibodies.
- To determine the effect of anti-T3 antibody on T cell functions.
Main Methods:
- Used five monoclonal anti-T cell reagents, an anti-Ia antibody, and an anti-beta 2-microglobulin antibody.
- Examined the impact of these antibodies on T cell proliferation, cytotoxic T cell generation, and T cell help for B cells.
Main Results:
- Anti-T3 antibody blocked T cell proliferative responses to antigens.
- Anti-T3 inhibited the generation of cytotoxic T cells but not their function once generated.
- Anti-T3 abrogated T cell help for B cell immunoglobulin production.
- Other tested monoclonal antibodies did not show these functional effects.
Conclusions:
- The T3 molecule's critical role in T cell function suggests it is involved in antigen recognition or cell-cell interactions.
- The T3 antigen's presence during thymic development further supports its significance in T cell biology.