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Related Experiment Videos

Cimetidine abrogates suppressor T cell function in vitro.

R Palacios, D Alarcon-Segovia

    Immunology Letters
    |April 1, 1981
    PubMed
    Summary
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    Cimetidine enhances human mononuclear cell proliferation and immunoglobulin production. This immune-modulating drug also significantly reduces the function of concanavalin-A-induced suppressor cells.

    Area of Science:

    • Immunology
    • Pharmacology

    Background:

    • Cimetidine is a histamine H2 receptor antagonist.
    • Its effects on human immune cells are not fully understood.

    Purpose of the Study:

    • To investigate the impact of cimetidine on normal human mononuclear cells.
    • To determine if cimetidine modulates immune cell suppressor function.

    Main Methods:

    • Human mononuclear cells were cultured with or without mitogenic stimuli (phytohemagglutinin, pokeweed mitogen).
    • Cells were treated with cimetidine, with varying incubation times.
    • [3H] thymidine incorporation and immunoglobulin production were measured.
    • Concanavalin-A-induced suppressor cell activity was assessed.

    Main Results:

    Related Experiment Videos

    • Cimetidine increased [3H] thymidine incorporation in unstimulated and mitogen-stimulated cells.
    • It enhanced immunoglobulin production under pokeweed mitogen stimulation.
    • Preincubation with cimetidine, compared to simultaneous addition, yielded higher stimulatory effects.
    • Cimetidine significantly decreased concanavalin-A-induced suppressor cell function.

    Conclusions:

    • Cimetidine exhibits immunomodulatory effects on human mononuclear cells.
    • It enhances cell proliferation and immunoglobulin synthesis.
    • Cimetidine abrogates suppressor cell activity, suggesting a role in modulating immune responses.