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Updated: Aug 11, 2026
14:23
Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
The characterization and function of human immunoregulatory T lymphocyte subsets
Pharmacological Reviews
|March 1, 1982
Summary
Human T lymphocyte subpopulations, inducer (T4) and suppressor (T5), are identified by surface antigens. Their balance is crucial for immune homeostasis, and imbalances can lead to disease.
Area of Science:
- Immunology
- Cell Biology
- Clinical Medicine
Background:
- T lymphocytes are crucial for immune regulation.
- Distinct T lymphocyte subpopulations, inducer (T4) and suppressor (T5), are defined by surface glycoprotein antigens.
- Immune homeostasis relies on the balance between these T-cell subsets.
Purpose of the Study:
- To discuss the current understanding of the T-cell circuit.
- To explore the role of T-cell subset dynamics in immunopathological disorders.
- To examine how T-cell subsets can be modulated to manipulate the human immune response.
Main Methods:
- Identification of T lymphocyte subpopulations using antibodies against specific surface glycoprotein antigens (T4 and T5).
- Analysis of the balance between inducer and suppressor T-cell subsets.
- Review of existing literature on T-cell subset function and disease pathogenesis.
Main Results:
- Inducer T lymphocytes are characterized by the T4 antigen.
- Suppressor T lymphocytes are characterized by the T5 antigen.
- Perturbations in the balance of T4 and T5 cells can lead to various immunopathological disorders.
Conclusions:
- The T-cell circuit, involving T4 and T5 subpopulations, is fundamental to immune homeostasis.
- Dysregulation of T-cell subset dynamics plays a role in disease pathogenesis.
- Targeted modulation of T-cell subsets offers a potential strategy for immune response manipulation.
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