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IgD values in children suffering from acute, recurrent and chronic respiratory diseases
Insights
Immunoglobulin D (IgD) levels were studied in 191 children with respiratory diseases. IgD increased significantly in tuberculosis, bronchial asthma, and bronchiectasis, but not in other acute respiratory conditions.
Area of Science:
- Pediatric Immunology
- Respiratory Medicine
- Clinical Biochemistry
Background:
- Respiratory diseases are common in children, with varying underlying etiologies.
- Immunoglobulin D (IgD) is an antibody isotype with a less understood role in immune responses compared to other immunoglobulins.
- Altered immunoglobulin levels can indicate underlying immune dysregulation in pediatric respiratory conditions.
Purpose of the Study:
- To investigate and compare serum Immunoglobulin D (IgD) levels in children diagnosed with various acute, recurrent, and chronic respiratory diseases.
- To determine if specific respiratory conditions are associated with elevated IgD concentrations.
- To explore potential correlations between IgD levels and the pathogenesis of pediatric respiratory illnesses.
Main Methods:
- Serum samples were collected from 191 children with diagnosed respiratory conditions.
- Immunoglobulin D (IgD) concentrations were quantified using the single radial immunodiffusion method.
- Results were expressed in International Units per milliliter (I.U./ml) and statistically analyzed.
Main Results:
- Children with acute bronchitis, bronchopneumonia, and recurrent obstructive bronchitis showed no significant increase in IgD levels compared to control groups.
- A significant increase (p < 0.05) in IgD values was observed in children with respiratory diseases of tuberculous etiology.
- Highly significant increases (p < 0.001) in IgD levels were found in children suffering from bronchial asthma and bronchiectasis.
Conclusions:
- Serum IgD levels are significantly elevated in children with bronchial asthma, bronchiectasis, and tuberculosis.
- The findings suggest a potential role for IgD in the immune response or pathogenesis of specific chronic and severe pediatric respiratory diseases.
- Further research is warranted to elucidate the factors influencing IgD synthesis and its specific contribution to these conditions.
Abstract:
In 191 children suffered from acute, recurrent and chronic respiratory diseases the IgD values were studied. The method of single radial immunodiffusion was used. The values obtained were expressed in I.U./ml. In children suffered from acute bronchitis, bronchopneumonia and recurrent obstructive bronchitis the IgD values were not increased in relation to group. In children suffered from diseases of tuberculous aetiology the IgD values were significantly increased, p less than 0.05. In children suffered from bronchial asthma and bronchiectasis the IgD values were highly significant increased, p less than 0.001. In discussion th author points at factors which influence the IgD synthesis and cause the increase of its values.