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[Gangliogliomas in cerebral hemisphere]
No Shinkei Geka. Neurological Surgery
|April 1, 1984
Summary
Gangliogliomas, rare brain tumors, often present as epilepsy and are best treated with surgical removal. Complete or near-complete recovery is common following surgical extirpation of these central nervous system neoplasms.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Neuropathology
Context:
- Gangliogliomas are uncommon tumors of the central nervous system.
- Diagnosis and treatment of these neoplasms can be challenging due to their rarity and varied presentations.
Purpose:
- To review the clinical features, radiological findings, and surgical outcomes of 6 patients with cerebral hemisphere gangliogliomas.
- To correlate histological findings with clinical presentation and treatment response.
Summary:
- Six patients (ages 8-58) with cerebral hemisphere gangliogliomas were analyzed. Five presented with intractable epilepsy, and one with focal neurological deficits.
- Radiological findings included abnormal calcification (3/6), avascular masses (6/6), and variable CT densities with slight mass effect (5/5). Tumors were located in the temporal or parietal lobes.
- Surgical outcomes were favorable, with complete or near-complete asymptomatic recovery in all patients after 1-12 years of follow-up, regardless of the extent of resection (total, subtotal, or partial). Histologically, astrocytic or oligodendroglial components predominated.
Impact:
- Highlights the epileptogenic nature of gangliogliomas and supports surgical intervention for optimal patient outcomes.
- Provides insights into the diagnostic imaging characteristics and histological variations of these rare brain tumors.
- Emphasizes the potential for significant recovery following surgical management, even with subtotal or partial resections.