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Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
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Published on: July 4, 2014

Once a day theophylline; serum concentrations

V Nerminathan, S A McKenzie

    Archives of Disease in Childhood
    |August 1, 1984
    PubMed

    Insights

    This study evaluated a new once-daily theophylline preparation in children with asthma. While peak levels coincided with likely nocturnal wheezing, daily concentration fluctuations were greater than existing treatments.

    Area of Science:

    • Pharmacology
    • Pediatric Pulmonology
    • Clinical Pharmacy

    Background:

    • Asthma management in children often involves theophylline.
    • Optimizing theophylline dosing is crucial for efficacy and safety.
    • Novel drug delivery systems aim to improve patient adherence and therapeutic outcomes.

    Purpose of the Study:

    • To assess the 24-hour serum concentration profiles of a new once-daily theophylline preparation in pediatric asthma patients.
    • To determine the pharmacokinetic characteristics of this novel formulation.
    • To correlate peak serum concentrations with symptom patterns, specifically nocturnal wheezing.

    Main Methods:

    • A cohort of 15 children with asthma participated in the study.
    • Serum theophylline concentrations were measured over a 24-hour period.
    • Pharmacokinetic parameters were analyzed for the new once-daily preparation.

    Main Results:

    • Peak serum theophylline concentrations were observed during the night, coinciding with the typical period of nocturnal wheezing.
    • The new preparation exhibited greater fluctuations in serum concentrations throughout the day compared to existing theophylline formulations.
    • The clinical significance of these observed fluctuations requires further investigation.

    Conclusions:

    • The new once-daily theophylline preparation achieves peak concentrations during a critical period for asthma symptom control in children.
    • The increased daily fluctuation warrants further study to ascertain its clinical impact and safety profile.
    • This formulation may offer an alternative for once-daily dosing, pending further evaluation of its variability.

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