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Effects of food on oxaprozin bioavailability
Journal of Clinical Pharmacology
|August 1, 1984
Summary
Food intake does not impact oxaprozin bioavailability. This study found no significant differences in key pharmacokinetic parameters when oxaprozin was taken with or without a meal.
Area of Science:
- Pharmacokinetics
- Drug Metabolism
- Clinical Pharmacology
Background:
- Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID).
- Understanding food's effect on drug absorption is crucial for optimal dosing.
- Previous studies on NSAID food interactions show variable results.
Purpose of the Study:
- To evaluate the effect of food on the oral bioavailability of oxaprozin.
- To compare pharmacokinetic parameters of oxaprozin under fasting and fed conditions.
Main Methods:
- A two-period crossover study in twelve healthy volunteers.
- Single 1200-mg oral doses of oxaprozin administered under fasting and fed states.
- Plasma oxaprozin concentrations monitored for 10 days post-dose.
Main Results:
- No statistically significant differences in Cmax, ka, or total AUC between fasting and fed states.
- A slight delay in gastrointestinal absorption onset (lag time) was observed in the fed state.
- Mean residence time and half-life showed minimal variation, likely due to intrasubject variability.
Conclusions:
- Food ingestion does not significantly affect the overall bioavailability of oxaprozin.
- Oxaprozin can be administered with or without food without compromising its absorption profile.
- These findings support flexible dosing recommendations for oxaprozin.