Additional alkaloids of Pachygone ovata

Area of Science:

• Phytochemistry
• Natural Products Chemistry
• Ethnobotany

Background:

• Pachygone ovata is a woody climber native to southern India.
• Its fruits have traditional uses as a rodenticide and fish poison.

Purpose of the Study:

• To isolate and characterize chemical constituents from the roots of Pachygone ovata.
• To identify novel alkaloid compounds with potential bioactivity.

Main Methods:

• Chromatographic separation techniques were employed to analyze root extracts.
• Spectroscopic data (NMR, MS) were used for structural elucidation.
• Chemical conversion was performed to confirm structural assignments.

Main Results:

• Reisolation of known alkaloids: liriodenine, coclaurine, trilobine, and magnoflorine.
• Isolation of five alkaloids: stepholidine, coreximine, isoboldine, norjuziphine, and the new compound nortrilobine.
• Nortrilobine was identified as a novel dibenzo-p-dioxin bisbenzylisoquinoline alkaloid.

Conclusions:

• The chemical investigation of Pachygone ovata roots yielded several known and one new bisbenzylisoquinoline alkaloid.
• Nortrilobine represents a new structural class within this alkaloid family.
• Further studies are warranted to explore the pharmacological properties of these isolated compounds.