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Choleretic response to hydrocortisone in the rabbit.
Revista Espanola De Fisiologia
|June 1, 1984
Summary
Hydrocortisone increases bile flow and electrolyte secretion in rabbits. However, it does not affect maximal bilirubin excretion when infused during a bilirubin load.
Area of Science:
- Hepatology and Pharmacology
- Biliary Physiology
Background:
- Biliary secretion is crucial for eliminating waste products like bilirubin.
- Hydrocortisone's role in modulating bile composition and flow requires further elucidation.
Purpose of the Study:
- To investigate the impact of hydrocortisone sodium succinate on basal bile secretion.
- To determine hydrocortisone's effect on maximal hepatic bilirubin excretion.
- To explore the mechanism of hydrocortisone's influence on bile flow.
Main Methods:
- Intravenous infusion of hydrocortisone sodium succinate in pentobarbital-anesthetized rabbits.
- Measurement of basal bile flow and electrolyte secretion.
- Assessment of maximal hepatic bilirubin excretion following a bilirubin load.
Main Results:
- Hydrocortisone significantly increased basal bile flow and electrolyte secretion.
- The choleretic effect of hydrocortisone was abolished when infused during a maximal bilirubin load.
- Maximal hepatic bilirubin excretion remained unchanged by hydrocortisone administration.
Conclusions:
- Hydrocortisone influences bile flow and composition at the canalicular level.
- The observed effects are independent of bile salt secretion.
- Hydrocortisone does not enhance the liver's maximal capacity to excrete bilirubin.