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[Glutathione and tissue uptake of triiodothyronine]
Annales D'Endocrinologie
|January 1, 1984
Abstract:
The effect of glutathione (GSH) on the 125I-Triiodothyronine uptake was studied in renal cortex slices. Addition of Diamide (30 mM), oxidizing reagent for GSH, to the incubation buffer decreases the hormonal uptake (-28%) while GSH (20mM) can reverse the effect of diamide. So the modification of T3 distribution previously shown in vitamin A-deficient rats can be attributed to the GSH deficiency already observed in these animals.