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Increased chromium uptake in polymorphonuclear leukocytes from burned patients.
The Journal of Trauma
|December 1, 1984
Summary
Neutrophil function is impaired after thermal injury, with reduced migration and altered chromium uptake. These findings suggest neutrophils may deplete cellular energy stores following severe burns.
Area of Science:
- Immunology
- Cellular Metabolism
- Burn Injury Research
Background:
- Neutrophil function is impaired post-thermal injury, with conflicting host metabolic states.
- Investigating neutrophil metabolism and function is crucial for understanding burn responses.
Purpose of the Study:
- To investigate neutrophil metabolism and function following thermal injury.
- To analyze neutrophil migration and chromium uptake in burn patients.
Main Methods:
- Utilized radio-labelled neutrophils to study migration and chromium uptake.
- Compared neutrophil migration (random and directed) and chromium influx in burn patients versus control subjects.
- Measured neutrophil and serum lysozyme content.
Main Results:
- Neutrophil migration was significantly reduced in burn patients.
- Neutrophil chromium uptake and influx velocity were significantly greater in burn patients compared to controls.
- Neutrophil lysozyme content was reduced, while serum lysozyme was elevated, suggesting release into circulation.
Conclusions:
- Thermal injury impairs neutrophil function, characterized by reduced migration and increased chromium uptake.
- Increased chromium influx may deplete cellular energy stores in neutrophils from burn patients.
- Lysozyme release from neutrophils into circulation is indicated.
