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Updated: Oct 7, 2026
Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
Published on: October 27, 2009
[Evaluation of pressure and mechanical effects on the aggregation of human platelets induced by adenosine diphosphate
Blood samples in sodium citrate 3.8% (ratio 1:10) of 15 healthy people were subjected to the pressure of 0, 50, 150 mm Hg respectively in a circuit operated by a peristaltic pump as during dialysis. The platelet aggregation induced by adenosine diphosphate (ADP) was determined in all cases. We found a significant reduction of the maximum percent aggregation of the samples exposed to the pressure of 150 mm Hg. We then suppose that a positive correlation exists between high pressure in the dialytic circuit and platelet damage.
Blood samples in sodium citrate 3.8% (ratio 1:10) of 15 healthy people were subjected to the pressure of 0, 50, 150 mm Hg respectively in a circuit operated by a peristaltic pump as during dialysis. The platelet aggregation induced by adenosine diphosphate (ADP) was determined in all cases. We found a significant reduction of the maximum percent aggregation of the samples exposed to the pressure of 150 mm Hg. We then suppose that a positive correlation exists between high pressure in the dialytic circuit and platelet damage.
