Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple system atrophy. Clinical aspects, pathophysiology, and treatment.

R J Polinsky

    Neurologic Clinics
    |August 1, 1984
    PubMed
    Summary

    Idiopathic orthostatic hypotension (IOH) and multiple system atrophy (MSA) are forms of autonomic failure. Differentiating them involves biochemical tests, revealing distinct norepinephrine levels and receptor sensitivities, guiding targeted treatments for autonomic dysfunction.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans.

    Journal of clinical psychopharmacology·1999
    Same author

    Separating the primary autonomic failure syndromes, multiple system atrophy, and pure autonomic failure from Parkinson's disease.

    Advances in neurology·1999
    Same author

    Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease.

    Clinical therapeutics·1998
    Same author

    Dose-dependent CSF acetylcholinesterase inhibition by SDZ ENA 713 in Alzheimer's disease.

    Acta neurologica Scandinavica·1998
    Same author

    Disorders of the autonomic nervous system.

    The New England journal of medicine·1997
    Same author

    Plasma sulfoconjugated dopamine levels are normal in patients with autonomic failure.

    The Journal of laboratory and clinical medicine·1996

    Area of Science:

    • Neurology
    • Autonomic Nervous System Research
    • Clinical Medicine

    Background:

    • Progressive autonomic failure encompasses autonomic dysfunction, presenting as idiopathic orthostatic hypotension (IOH) or multiple system atrophy (MSA).
    • Distinguishing between MSA and IOH is crucial for effective management.
    • Autonomic dysfunction can arise from peripheral or central nervous system defects.

    Purpose of the Study:

    • To differentiate between idiopathic orthostatic hypotension (IOH) and multiple system atrophy (MSA).
    • To elucidate the underlying mechanisms of autonomic dysfunction in IOH and MSA.
    • To inform therapeutic strategies for autonomic failure.

    Main Methods:

    • Biochemical and pharmacologic testing to assess plasma norepinephrine levels and pressor responses.

    Related Experiment Videos

  • Evaluation of adrenergic receptor sensitivity.
  • Neuropathologic examination of central nervous system tissues.

    • Main Results:

    • Plasma norepinephrine levels are low in IOH and normal in MSA.
    • Both conditions show inadequate norepinephrine response to postural changes and exaggerated response to administered norepinephrine.
    • IOH exhibits true adrenergic receptor supersensitivity, while MSA shows impaired sympathetic nervous system activation.

    Conclusions:

    • Autonomic dysfunction in IOH involves peripheral neurons, whereas MSA involves central failure in sympathetic activation.
    • Neuropathology reveals multisystem degeneration in MSA and spinal cord lesions in IOH.
    • Therapeutic options for orthostatic hypotension are limited by supine hypertension; sympathetic neural prostheses may offer future solutions.