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Updated: Jul 7, 2026
08:52
Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
Published on: February 17, 2015
Steps towards the development of a safe and effective tachycardia terminating pacemaker
European Heart Journal
|December 1, 1984
Summary
Permanent pacemakers effectively treat tachycardias using advanced pacing algorithms. Adaptive burst pacing is most effective, though reset methods show inconsistent results in atrial pacing.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- Permanent pacemakers are utilized for treating tachycardias.
- Four studies investigated improved termination algorithms for pacemakers.
Purpose of the Study:
- To evaluate the efficacy of different pacing algorithms in terminating tachycardias.
- To assess the effectiveness and safety of permanent extrastimulus, autodecremental, and concertina pacing.
Main Methods:
- Permanent extrastimulus pacing in 19 patients.
- Autodecremental (rate-increasing) atrial pacing in 20 patients with junctional arrhythmias.
- Concertina pacing (up to 7 stimuli) in 19 patients.
Main Results:
- Pacing was effective in all patients, but 7 required additional antiarrhythmic drugs and one experienced sudden death.
- Autodecremental pacing was effective, especially with a 5000 ms burst duration, without accelerating tachycardia.
- Concertina pacing was effective; however, short bursts induced arrhythmias, while longer bursts with longer cycle lengths were effective. Ventricular pacing caused reset, but atrial pacing results were inconsistent.
Conclusions:
- Adaptive, limited burst pacing modes are the most effective for tachycardia termination.
- Reset is not a consistently useful method in the right atrium for tachycardia termination.
- While effective, certain pacing strategies carry risks, including arrhythmias and sudden death.
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