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Monozygotic twins from in vitro fertilization.
Fertility and Sterility
|June 1, 1984
Summary
Identical twins can occur after in vitro fertilization and embryo transfer (IVF-ET), even when multiple embryos are transferred. This case suggests the division of a single embryo post-implantation, not related to IVF-ET technique.
Area of Science:
- Reproductive Medicine
- Genetics
- Obstetrics
Background:
- Identical twinning is a rare event.
- In vitro fertilization and embryo transfer (IVF-ET) involves transferring embryos into the uterus.
- Understanding twinning mechanisms is crucial for reproductive outcomes.
Observation:
- A case of identical male twins is described following IVF-ET.
- Two embryos were transferred, but only one appeared to implant.
- The twins shared a monochorionic, diamniotic placental and membrane configuration.
Findings:
- The identical twins likely resulted from the division of a single implanted embryo.
- Marker studies indicated a very low probability (<0.001) of dizygosity (fraternal twins).
- The occurrence of identical twinning was deemed unlikely to be related to the IVF-ET procedure itself.
Implications:
- This case highlights that spontaneous monozygotic twinning can occur post-implantation, irrespective of embryo number transferred in IVF-ET.
- Further research may elucidate the precise mechanisms influencing early embryonic division.
- Clinical management of IVF-ET cycles should consider the possibility of monozygotic twinning from a single embryo.