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[Plasmatic levels of gastrin in children under seven years (author's transl)]
Insights
This study measured gastrin levels in 100 healthy children aged 3 months to 7 years. No significant differences were found across age groups, establishing normal gastrinemia ranges for pediatric populations.
Area of Science:
- Pediatric Endocrinology
- Gastroenterology
- Clinical Chemistry
Context:
- Gastrin plays a crucial role in regulating gastric acid secretion and mucosal growth.
- Establishing normative data for hormones like gastrin is essential for diagnosing various gastrointestinal and endocrine disorders in children.
- Previous studies on pediatric gastrin levels have been limited, necessitating further research.
Purpose:
- To determine the normal range of gastrinemia in healthy children aged three months to seven years.
- To investigate potential age-related variations in gastrin levels within this pediatric cohort.
- To establish reference percentiles for gastrinemia for clinical and research applications.
Summary:
- Gastrin levels were measured in 100 healthy children (3 months to 7 years) using radioimmunoassay.
- Participants were divided into three age groups, with no significant differences observed in gastrinemia among them.
- The study established a 5th to 95th percentile range for gastrinemia, with an average of 76.81 pcg./ml (50th percentile).
Impact:
- Provides essential normative data for pediatric gastrin levels, aiding in the diagnosis of related conditions.
- Facilitates accurate interpretation of gastrin measurements in pediatric clinical practice.
- Serves as a reference for future research on gastrin's role in childhood gastrointestinal health and disease.
Abstract:
Gastrinemia was determined in 100 healthy children whose ages ranged from three months to seven years, who were separated in three groups: from three months to two years, from two to four years, determining the gastrin by radioinmunoassay twice in each case. As no significant difference was found among the three groups, total results were grouped together to confect a graph ranging from the 5th to the 95th percentile. Average percentage of gastrinemia was determined at 76.81 pcg./ml. (50 percentile), with extreme values between 48.31 pcg./ml. (5th percentile) and 105.31 pcg./ml. (95th percentile).