Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothalamic-pituitary-adrenal-axis hyperactivity in bulimia.

J I Hudson, H G Pope, J M Jonas

    Psychiatry Research
    |February 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Anabolic-Androgenic Steroid Use Among 1,010 College Men.

    The Physician and sportsmedicine·2016
    Same author

    Therapy of adrenocortical cancer with o,p' DDD in two children.

    The Journal of clinical endocrinology and metabolism·2014
    Same author

    Attributes of long-term heavy cannabis users: a case-control study.

    Psychological medicine·2003
    Same author

    Family study of the aggregation of eating disorders and mood disorders.

    Psychological medicine·2003
    Same author

    Bilateral testicular enlargement due to adrenal remnant in a patient with C11 hydroxylase deficiency congenital adrenal hyperplasia.

    Journal of endocrinological investigation·2003
    Same author

    Delayed disclosure by victims of child sexual abuse: an important topic for study.

    Acta paediatrica (Oslo, Norway : 1992)·2003

    Forty-seven percent of patients with bulimia exhibited hypothalamic-pituitary-adrenal axis hyperactivity, indicated by nonsuppression of plasma cortisol in the dexamethasone suppression test (DST). This prevalence mirrors that found in major depression, suggesting a link to affective disorders.

    Area of Science:

    • Neuroendocrinology
    • Psychiatry
    • Clinical Psychology

    Background:

    • The hypothalamic-pituitary-adrenal (HPA) axis is frequently hyperactive in major depression, evidenced by cortisol nonsuppression in the dexamethasone suppression test (DST).
    • Bulimia nervosa shares phenomenological, familial, and treatment response similarities with affective disorders, hinting at a potential neurobiological overlap.

    Purpose of the Study:

    • To investigate the prevalence of HPA axis hyperactivity in patients diagnosed with bulimia nervosa.
    • To compare the DST nonsuppression rates between individuals with bulimia and healthy controls.

    Main Methods:

    • The dexamethasone suppression test (DST) was administered to 47 patients with bulimia and 22 age- and sex-matched healthy controls.
    • Plasma cortisol levels were measured to assess nonsuppression, a marker of HPA axis hyperactivity.

    Related Experiment Videos

    Main Results:

    • A significant proportion (47%) of patients with bulimia were identified as DST nonsuppressors.
    • The prevalence of DST nonsuppression in the bulimia group was significantly higher than in the control group (9%).
    • The observed rate of DST nonsuppression in bulimia patients aligns with rates reported for major depression.

    Conclusions:

    • Bulimia nervosa may be associated with HPA axis hyperactivity, similar to major depression.
    • These findings support the hypothesis that bulimia nervosa shares underlying biological mechanisms with affective disorders.
    • Further research into the neurobiology of bulimia is warranted, focusing on its relationship with mood disorders.