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Related Experiment Videos

Naloxone does not antagonize leukocytic pyrogen.

W G Clark, N F Harris

    European Journal of Pharmacology
    |June 1, 1978
    PubMed
    Summary

    Naloxone hydrochloride did not prevent fever responses to leukocytic pyrogen in cats, suggesting endogenous opioid peptides are not central mediators of fever. This research impacts our understanding of fever mechanisms.

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    Area of Science:

    • Neuroscience
    • Immunology
    • Pharmacology

    Background:

    • Fever is a complex physiological response involving the immune system.
    • Endogenous opioid peptides are implicated in various physiological processes, including pain and stress.
    • The role of opioid peptides in fever regulation remains unclear.

    Purpose of the Study:

    • To investigate the potential role of endogenous opioid peptides in mediating pyrogen-induced fevers.
    • To determine if naloxone hydrochloride, an opioid receptor antagonist, can block fever responses.

    Main Methods:

    • A crossover experiment was conducted on cats.
    • Cats received third cerebral ventricular injections of naloxone hydrochloride or saline.
    • Subsequent intravenous injections of leukocytic pyrogen were administered to assess fever responses.

    Main Results:

    • Leukocytic pyrogen induced comparable fevers in cats pretreated with either naloxone hydrochloride or saline.
    • Intravenous administration of naloxone hydrochloride did not inhibit fever responses to leukocytic pyrogen.

    Conclusions:

    • The findings suggest that endogenous opioid peptides are unlikely to be central mediators of pyrogen-induced fevers.
    • Opioid systems may not play a significant role in the central regulation of fever in this model.

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