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Sex selection by sperm separation and insemination.
Fertility and Sterility
|November 1, 1984
Summary
This study demonstrates sperm separation techniques can enrich for Y or X sperm, enabling couples to select the sex of their infant. The albumin filtration method achieved 80% male births, while Sephadex gel filtration showed promise for female selection.
Area of Science:
- Reproductive biology
- Genetics
- Medical technology
Background:
- Sperm sorting techniques are crucial for reproductive choices and preventing sex-linked genetic disorders.
- Selective insemination aims to control offspring sex based on parental preference or medical necessity.
Purpose of the Study:
- To evaluate the efficacy of sperm separation methods for sex selection in human conception.
- To determine the success rates of achieving desired offspring sex using albumin and Sephadex gel filtration.
Main Methods:
- The Ericsson albumin filtration technique was employed to isolate Y-chromosome-bearing sperm for male-biased insemination.
- A Sephadex gel filtration system was utilized to enrich for X-chromosome-bearing sperm for female-biased insemination.
Main Results:
- Using albumin filtration, 35 conceptions resulted in 28 males (80%).
- With Sephadex gel filtration, 12 pregnancies yielded 7 females, 2 males, and 1 set of twins (one of each sex).
Conclusions:
- Sperm separation techniques offer a viable method for elective sex selection.
- Female sex selection is also indicated for avoiding the transmission of sex-linked diseases in carrier mothers.
Keywords:
Artificial InseminationBiologyDemographic FactorsExaminations And DiagnosesGeneticsGenitaliaGenitalia, MaleGerm CellsLaboratory Examinations And DiagnosesNeonatal Diseases And AbnormalitiesPennsylvaniaPhysiologyPopulationPopulation DynamicsReproductionReproductive TechnologiesSemen--analysisSeminal VesiclesSex PreselectionSpermatozoaTime FactorsUrogenital System