Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Implant material tolerance.

P Josset, B Meyer, D Gegu

    Acta Oto-Laryngologica. Supplementum
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Cochlear implants in guinea pigs show stable electrical thresholds despite cochlear lesions. Chronic stimulation prevents nerve atrophy, suggesting potential for long-term auditory function restoration.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Rb-loss is associated with high malignancy in chondrosarcoma.

    Oncology reports·2005
    Same author

    Pellucid marginal degeneration coexistent with cornea plana in one member of a family exhibiting a novel KERA mutation.

    The British journal of ophthalmology·2005
    Same author

    A fluorometric method for the differentiation of algal populations in vivo and in situ.

    Photosynthesis research·2005
    Same author

    "Best friends" sharing the HMGA1 gene: comparison of the human and canine HMGA1 to orthologous other species.

    The Journal of heredity·2005
    Same author

    Intermittent administration of betalactam-antibiotics for treatment of severe infection in hemodialysis patients.

    European journal of medical research·2005
    Same author

    Pharmacokinetics of teicoplanin during continuous hemofiltration with a new and a 24-h used highly permeable membrane: rationale for therapeutic drug monitoring-guided dosage.

    International journal of clinical pharmacology and therapeutics·2004
    Same journal

    Towards a consensus on a hearing preservation classification system.

    Acta oto-laryngologica. Supplementum·2013
    Same journal

    Inner ear drug delivery system from the clinical point of view.

    Acta oto-laryngologica. Supplementum·2010
    Same journal

    Hydrogen protects vestibular hair cells from free radicals.

    Acta oto-laryngologica. Supplementum·2010
    Same journal

    Distribution of bone marrow-derived cells in the vestibular end organs and the endolymphatic sac.

    Acta oto-laryngologica. Supplementum·2010
    Same journal

    Impacts and limitations of medialization thyroplasty on swallowing function of patients with unilateral vocal fold paralysis.

    Acta oto-laryngologica. Supplementum·2010
    Same journal

    A tissue-engineering approach for stenosis of the trachea and/or cricoid.

    Acta oto-laryngologica. Supplementum·2010
    See all related articles

    Area of Science:

    • Otolaryngology
    • Biomedical Engineering
    • Neuroscience

    Background:

    • Surgical destruction of guinea pig cochleas results in non-specific lesions.
    • These lesions appear to be primarily caused by the surgical procedure rather than electrode implantation or chronic stimulation.

    Purpose of the Study:

    • To evaluate the long-term stability of electrical thresholds in implanted guinea pigs.
    • To investigate the effect of chronic electrical stimulation on preventing cochlear nucleus atrophy in deafened animals.
    • To assess the biocompatibility and long-term performance of cochlear implant materials and placement in humans.

    Main Methods:

    • Surgical and antibiotic destruction of guinea pig cochleas followed by electrode implantation and chronic stimulation.
    • Measurement of electrical threshold levels for brainstem evoked responses.

    Related Experiment Videos

  • Histological examination to assess cochlear nucleus atrophy.
  • Clinical observation of implanted patients regarding material tolerance, electrode placement, and infection rates.

    • Main Results:

    • Electrical threshold levels remained stable over time in implanted guinea pigs, despite cochlear lesions.
    • Chronic electrical stimulation prevented cochlear nucleus atrophy in deafened guinea pigs.
    • Implanted materials showed excellent tolerance in humans when properly shielded and placed, with degradation only occurring due to chronic movement.
    • High voltage stimulation could cause temporary failure due to bubble formation, mitigated by enlarged electrode tips.
    • Threshold levels and frequency discrimination remained unchanged for over 6 years.
    • Post-operative infections, initially linked to pre-operative otitis or specific adhesives, were eliminated with improved surgical techniques and materials.

    Conclusions:

    • Cochlear implantation is a viable strategy for preserving auditory nerve function and preventing neural degeneration.
    • Careful material selection, shielding, and electrode placement are crucial for long-term biocompatibility and device function in humans.
    • Optimized stimulation parameters and surgical protocols minimize risks such as temporary system failure and post-operative infections.