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Updated: Aug 14, 2026
14:40
Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
Published on: October 25, 2015
Foetal steroid sulphatase deficiency. A case report
Scottish Medical Journal
|July 1, 1984
Summary
Low maternal urinary oestrogen levels during pregnancy may indicate a risk of ichthyosis in male infants. A family history of x-linked ichthyosis should be considered in such cases.
Area of Science:
- Perinatology
- Medical Genetics
- Dermatology
Background:
- Pregnancy monitoring involves assessing maternal hormone levels, including urinary oestrogens.
- Low maternal urinary oestrogen excretion can be associated with various pregnancy complications.
- Ichthyosis is a group of genetic skin disorders characterized by dry, scaling skin.
Observation:
- A male infant was delivered via caesarean section due to low maternal urinary oestrogen excretion.
- The infant later developed ichthyosis, a condition causing dry, thickened skin.
- A family history of x-linked recessive ichthyosis was noted in the infant's lineage.
Findings:
- The case suggests a potential link between low maternal urinary oestrogens and the development of ichthyosis in male offspring.
- The presence of a family history of x-linked ichthyosis strengthens this association.
- Unexplained low maternal urinary oestrogen levels may serve as an early indicator.
Implications:
- Clinicians should consider inquiring about a family history of ichthyosis ('dry skin' conditions) when encountering unexplained low maternal urinary oestrogen levels.
- This association may aid in the early identification and management of infants at risk for genetic skin disorders.
- Further research is warranted to elucidate the specific mechanisms connecting maternal oestrogen levels and fetal ichthyosis development.
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