Related Experiment Videos
[Etiology of the infectious process in chronic pneumonia in children]
Abstract:
During the phase of exacerbation in chronic pneumonia in children Streptococcus pneumoniae and/or Haemophilus influenzae were isolated practically from all patients under examination. In the mild form of chronic pneumonia in children the high occurrence of H. influenzae (65.5-69%) was observed. During the whole acute phase of the disease, irrespective of the activity of the infectious process and the character of therapeutic measures, the degree of contamination of bronchial washings from the patients with these microorganisms was 5.95-6.6 lg/ml. In the bronchiectatic variant of chronic pneumonia the high activity and stability of the infectious processes induced by S. pneumoniae and H. influenzae were found to be linked with the considerable spread of these processes or with deeper morphological and functional changes in the bronchial stem and branches. During the phase of clinical remission in chronic pneumonia in 36.8-58.8% of children the release of S. pneumoniae and H. influenzae was observed. The geometric mean of their concentration varied within 3-5.3 lg/ml.
Insights
Streptococcus pneumoniae and Haemophilus influenzae are prevalent in pediatric chronic pneumonia, especially during exacerbations. Their presence and concentration correlate with disease severity and bronchial changes.
Area of Science:
- Pediatric Pulmonology
- Microbiology
- Infectious Diseases
Background:
- Chronic pneumonia in children presents diagnostic and therapeutic challenges.
- Identifying key pathogens is crucial for understanding disease progression.
Purpose of the Study:
- To investigate the prevalence and role of Streptococcus pneumoniae and Haemophilus influenzae in pediatric chronic pneumonia.
- To correlate pathogen presence with disease severity and clinical presentation.
Main Methods:
- Bacteriological examination of bronchial washings from pediatric patients with chronic pneumonia.
- Analysis of pathogen isolation rates and concentrations during different disease phases (exacerbation, remission).
- Correlation of microbial findings with clinical and morphological characteristics of the disease.
Main Results:
- Streptococcus pneumoniae and Haemophilus influenzae were frequently isolated during exacerbations.
- Haemophilus influenzae showed high occurrence (65.5-69%) in mild forms of chronic pneumonia.
- Pathogen concentrations remained high (5.95-6.6 lg/ml) during the acute phase.
- In bronchiectatic variants, high pathogen activity correlated with disease spread and bronchial changes.
- These bacteria were still detected in 36.8-58.8% of children during clinical remission.
Conclusions:
- Streptococcus pneumoniae and Haemophilus influenzae are significant pathogens in pediatric chronic pneumonia.
- Their persistence and concentration are linked to disease severity and bronchopulmonary changes.
- Understanding pathogen dynamics is vital for managing chronic pediatric respiratory infections.