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Related Experiment Videos

Changes in pulmonary diffusing capacity and closing volume after running a marathon.

D S Miles, C E Doerr, S A Schonfeld

    Respiration Physiology
    |June 1, 1983
    PubMed
    Summary
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    Marathon running did not cause small airway obstruction. However, increased closing volumes (CV) and alveolar-capillary membrane resistance suggest potential subclinical edema, impacting lung elastic recoil.

    Area of Science:

    • Exercise Physiology
    • Pulmonary Medicine
    • Respiratory Physiology

    Background:

    • Marathon running is a strenuous endurance event.
    • Understanding the impact of prolonged exercise on lung function is crucial.

    Purpose of the Study:

    • To evaluate changes in pulmonary function following marathon completion.
    • To investigate potential small airway obstruction and alveolar-capillary membrane changes.

    Main Methods:

    • Pulmonary function tests were performed on 8 male runners before, immediately after, and 24 hours post-marathon.
    • Tests included lung volumes, flow rates (FEV1), closing volumes (CV), and diffusing capacity (DLCO, Vc, DM) using spirometry and gas dilution techniques.

    Main Results:

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  • No significant changes in lung volumes or maximal flow rates were observed, except for an increased FEV1.
  • Significant decreases in pulmonary diffusing capacity (DLCO) and membrane diffusing capacity (DM) were noted post-race.
  • Closing volumes (CV) increased significantly, while pulmonary capillary blood volume (Vc) remained unchanged.

    • Conclusions:

    • Marathon running does not appear to cause small airway obstruction.
    • Increased alveolar-capillary membrane resistance and closing volumes may indicate subclinical pulmonary edema.
    • These changes could lead to decreased lung elastic recoil, explaining the observed increase in closing volumes.