Related Experiment Videos
Spiking fever induced by isoniazid
Drug Intelligence & Clinical Pharmacy
|October 1, 1983
Summary
Isoniazid, a tuberculosis drug, can cause fever as a hypersensitivity reaction. This patient experienced recurring fever linked to isoniazid, but not rifampin, confirming the drug as the cause.
Area of Science:
- Infectious Diseases
- Pharmacology
- Clinical Medicine
Background:
- Tuberculosis (TB) treatment commonly involves combination therapy.
- Isoniazid and rifampin are cornerstone drugs for TB.
- Adverse drug reactions can complicate treatment regimens.
Purpose of the Study:
- To investigate a case of drug-induced fever during tuberculosis treatment.
- To identify the specific causative agent of the fever between isoniazid and rifampin.
Main Methods:
- Clinical observation of a patient undergoing TB therapy.
- Drug rechallenge to assess causality of adverse events.
- Monitoring of patient's temperature and clinical status.
Main Results:
- A 48-year-old male patient developed spiking fevers 10 days after starting isoniazid and rifampin.
- Fever resolved upon discontinuation of both drugs.
- Recurrence of fever was observed upon rechallenge with isoniazid, but not rifampin.
Conclusions:
- Isoniazid is a potential cause of drug-induced fever.
- The fever is likely a hypersensitivity reaction to isoniazid.
- This case highlights the importance of considering drug hypersensitivity in TB treatment.