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[Tar treatment in dermatology].
Summary
Coal tar, used in dermatology, contains the carcinogen benzo(a)pyrene. Topical application can induce liver and skin enzymes, leading to mutagenic urine, suggesting caution is warranted.
Area of Science:
- Dermatology
- Toxicology
- Biochemistry
Context:
- Coal tar is a traditional therapeutic agent in dermatologic practice.
- Concerns exist regarding its carcinogenic potential.
- Benzo(a)pyrene, a known carcinogen, is a component of coal tar preparations.
Purpose:
- To investigate the biochemical and toxicological effects of coal tar, specifically benzo(a)pyrene.
- To assess the systemic impact of topical coal tar application.
Summary:
- Coal tar contains benzo(a)pyrene, a potent inducer of aryl hydrocarbon hydroxylase activity in the liver and skin.
- This enzyme catalyzes the formation of reactive benzo(a)pyrene metabolites.
- Topical coal tar application results in altered urine mutagenicity, indicating systemic effects.
Impact:
- Highlights the need for caution when using coal tar therapeutically due to its carcinogenic components.
- Suggests potential risks beyond localized skin treatment.
- Informs clinical practice and risk-benefit assessments for coal tar therapies.