A fatal overdose with clomipramine

A death attributed to self administration of toxic amounts of clomipramine is reported. Analysis of post mortem blood showed clomipramine at a concentration of 540 ng/mL and its active metabolite, N-desmethylclomipramine, at a concentration of 580 ng/mL. The corresponding concentrations of the parent compound and metabolite in the urine were only 350 ng/mL and 700 ng/mL, respectively. These blood results are construed to represent minimum lethal concentrations for the two combined compounds.