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Related Experiment Videos

A fatal overdose with clomipramine.

R C Meatherall, D R Guay, J L Chalmers

    Journal of Analytical Toxicology
    |July 1, 1983
    PubMed
    Summary

    A death linked to clomipramine overdose is detailed. Post-mortem blood analysis revealed high levels of clomipramine and its metabolite, suggesting these concentrations were lethal.

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    Area of Science:

    • Forensic Toxicology
    • Clinical Pharmacology

    Background:

    • Clomipramine is a tricyclic antidepressant.
    • Overdose can lead to severe toxicity.

    Observation:

    • A fatal case of self-administered clomipramine overdose was investigated.
    • Post-mortem blood and urine samples were analyzed.

    Findings:

    • Blood clomipramine concentration was 540 ng/mL.
    • Blood N-desmethylclomipramine concentration was 580 ng/mL.
    • These levels are considered minimum lethal concentrations when combined.

    Implications:

    • Highlights the toxicity of clomipramine in overdose.
    • Provides reference concentrations for forensic and clinical toxicology.
    • Underscores the importance of therapeutic drug monitoring.