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[Lung tissue alterations following experimental infection of mice with acholeplasmae isolated from simians with
Abstract:
This paper is devoted to the study of pathogenic acholeplasmae potencies. Two strains of acholeplasmae isolated from the blood and organs of Papio hamadryas suffering from hemoblastosis and a standard Ach. laidlawii A. strain were subjected to the comparative study with the use of a "pulmonary model" in experiments on mice. Morphological investigations showed affections of the pulmonary tissue characterized by stage-by-stage inflammatory-destructive changes analogous to the lesions found in "mycoplasmosis of the lungs". Prolonged inflammatory changes in the pulmonary tissue were maintained by a long-term persistence of acholeplasmae in it. A conclusion was drawn that acholeplasmae isolated from monkeys suffering from hematosarcoma had marked pathogenic action on the pulmonary tissue of mice. Strain differences in the pathogenic activity of the strains under study were revealed.
Insights
Pathogenic acholeplasmae strains isolated from monkeys caused lung damage in mice, similar to mycoplasmosis. Strain differences in pathogenicity were observed, highlighting acholeplasmae's potential as a lung pathogen.
Area of Science:
- Veterinary Pathology
- Microbiology
- Infectious Diseases
Context:
- Acholeplasma are a genus of mollicutes that can be associated with disease in various animal species.
- Monkeys with hemoblastosis (a type of hematosarcoma) yielded two Acholeplasma strains for study.
- A standard Acholeplasma laidlawii A strain was used for comparative analysis.
Purpose:
- To comparatively assess the pathogenic potential of Acholeplasma strains isolated from diseased non-human primates.
- To investigate the effects of these strains on the pulmonary tissue of a murine model.
- To identify strain-specific differences in pathogenicity.
Summary:
- Two Acholeplasma strains from Papio hamadryas with hemoblastosis, alongside Ach. laidlawii A, were tested using a mouse pulmonary model.
- Morphological analysis revealed progressive inflammatory and destructive changes in mouse lungs, resembling mycoplasmosis lesions.
- Persistent Acholeplasma infection in lung tissue prolonged inflammatory responses.
Impact:
- Acholeplasma strains from monkeys with hematosarcoma demonstrated significant pathogenicity towards mouse pulmonary tissue.
- The study identified distinct variations in pathogenic activity among the tested Acholeplasma strains.
- Findings contribute to understanding Acholeplasma as a potential pulmonary pathogen and highlight strain variability.