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[Qualitative features of erythropoiesis in rabbits following multiple antigenic stimulation]

L N Sorokina, N V Vasil'ev, V A Kolaev

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |March 1, 1978
    PubMed

    Experiments were conducted on rabbits; a study was made of the influence of multiple antigen stimulation on the indices of erythropoiesis. Isotonic physiological saline was administered daily in control rabbits. The erythroid bone marrow series responded in the same direction both to the antigen and to the non-antigen stimulation. There was noted an increase of the percentage content of macrocytes, coinciding in time with reticulocytosis in the immunized animals at the second stage (the 50th day). Normalization of the character of the erythrocyte distribution occurred in the control group at this period. In case of empolyment of the antigen stimulation, the second stage can be regarded as the compensatory-regenerative response to the damaging action of the antigen.

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