A case of localized Darier's disease

Area of Science:

• Dermatology
• Genetics
• Histopathology

Background:

• Darier's disease is a rare autosomal dominant genodermatosis.
• Localized Darier's disease presents as a rare variant with distinct clinical manifestations.
• Understanding localized Darier's disease is crucial for accurate diagnosis and management.

Observation:

• A 36-year-old Japanese woman presented with a 16-year history of hyperkeratotic papules.
• Lesions were arranged in a zosteriform pattern on the left forehead.
• Histopathological examination confirmed features consistent with classical Darier's disease.

Findings:

• The patient exhibited skin atrophy secondary to prolonged corticosteroid ointment use.
• Topical aromatic retinoid ointment demonstrated significant efficacy in treating the localized Darier's disease lesions.
• This case contributes to the understanding of localized Darier's disease treatment outcomes.

Implications:

• Localized Darier's disease requires careful differential diagnosis from other dermatoses.
• Aromatic retinoids offer a viable therapeutic option for localized Darier's disease.
• Further research into localized Darier's disease variants may refine treatment strategies.