Reduction of polypharmacy for epilepsy in an institution for the retarded

It is a well-established fact that 20 to 40 per cent of patients in residential institutions for the retarded have seizures and take anticonvulsants. Most patients have quiescent seizure disorders and can manage well on monotherapy. In this study, 78 per cent of the patients remained seizure-free after switching from multiple-drug regimens to monotherapy.