Albumin determination with bromocresol purple: imprecision, comparison of methods and quality control

The bromocresol purple methods for the determination of serum albumin on the Du Pont aca and on the KONE CD show very acceptable linear ranges and imprecision data. Comparison of methods showed good agreement between albumin determinations on the two instruments. Human based quality control materials are required in order to monitor the accuracy of bromocresol purple methods, and to obtain results that are independent of method or instrument. Assigned values in assayed controls and external quality control schemes based on the bromocresol green method are not suitable.